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April/May 2008

Wine & Health: An Answer to the French Paradox?

Leave it to the Brits to solve a French puzzle...

The most famous of all Wine & Health findings has to be the so-called French Paradox. That is, how can you explain France’s relatively low rate of deaths from heart disease in light of its relatively high fat diet (foie gras, cheese, cream, butter, etc.)? The answer for a number of years has seemed to be France’s relatively high red wine consumption, attributed to raising HDL levels ("good cholesterol") and widening the diameter of arteries.

Scientists from London’s Queen Mary University have just released preliminary findings that the polyphenols in red wine may in fact slow down the rate at which a certain peptide in the blood stream, called endothelin-1, excessive amounts of which can result in fatty artery-blocking deposits.

Interestingly, white wines and rosés did not affect the peptide rate. Furthermore, the more polyphenols in the red wine, the more dramatically the peptide rate was slowed. The researchers tested a number of red wine varietals (Merlot, Pinot Noir, Shiraz, etc.), with the Cabernet Sauvignon having the most effect.

The team of scientists plans to continue to narrow down the particular polyphenol that seems to be having the effect, as well as conduct tests on humans. So far, the experiments have been limited to cultivated cow cells.

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